Virology, Emerging Diseases & vaccines

Oncogenic Virus

Oncogenic viruses are the kind of virus that causes cancer. DNA viruses such as HPV,Epstein-Barr virus, Human cytomegalo virus causes cancer. RNA Virus such as Retroviruses causes cancer. Human Immunodeficiency Virus is a lentivirus which is one of the retrovirus that causes AIDS in humans which leads cancers to thrive.  Gag-Onc fusion protein is a fusion protein which plays a major role in development of cancer. Gag genes are the part of retroviruses which plays a role in the process of reverse transcription. Hodgkin’s lymphoma or Hodgkin’s disease is a kind of a lymphoma in which cancer originates from white blood cells. Radiation therapy,chemotherapy and hematopoietic stem cell transplantation  are the treatment methods for hodgkin’s disease. Adult T-cell Leukemia is a rare cancer that occurs in T-cell.Zidovudine,Pralatrexate and CHOP regimen(Cyclophosphamide-Hydroxydaunorubicin-Oncovin-Prednisolone) are the medications for the treatment of Adult T-cell Leukemia. Oncogenes  are the group of genes that has a potential to cause cancer. In tumour cells oncogenes are mutated or expressed at higher levels. Mytogens,Receptor tyrosine Kinases,Regulatory GTPases are some of the oncogenes. In Carcinogenesis  normal cells are being transformed into cancer cells.Characterized by uncontrolled cell division which results in formation of malignant mass. Oncolytic virus  are the group of virus that preferentially infects and kills cancer cells. New castle disease virus,reovirus are preferentially used as oncolytic agents.