Structural and Molecular virology

Molecular virology refers to the study of viruses at the molecular level which involves the analysis of genes and gene products of viruses and study their interaction with host (human, plant or animal) cellular proteins. Structural Virology is the molecular mechanism used by viruses to invade host cells establish an infection and ensure that progeny virus particles are released into the environment, all while evading the host's immune defences. Viruses are the smallest self -replicating organisms. Even though individually viruses are rather simple, as a group they are exceptionally diverse in both replication strategies and structures. Many viruses are important human pathogens.

To study the life cycle of human virus, we use various technologies like X-ray crystallography, cryo-electron microscopy. We investigate macromolecular interactions associated with virus cell entry, genome replication, assembly, and maturation. Viruses are very simple enough that we can aspire to understand their biology at a molecular level. Our efforts are directed towards using structural information for the development of anti-viral drugs and vaccines.

 

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