Samina Mukry
National Institute of Blood Diseases & Bone Marrow Transplantation, Pakistan
Title: Haemostatic defects in Dengue hemorrhagic fever in a tertiary care hospital in Karachi
Biography
Biography: Samina Mukry
Abstract
Dengue is an increasingly important mosquito borne viral infection in the tropical and sub-tropical regions of the world. Dengue fever (DF) and Dengue hemorrhagic fever (DHF) are two clinical manifestations presenting severe thrombocytopenia with mild cutaneous hemorrhages. The DHF is characterized by plasma leakage and shock due to increase in vascular permeability leading to defects in the first phase of haemostasis. Exact cause of this is still obscured. In order to investigate haemostatic defects in DHF; 306 dengue suspected patients of either sex visiting NIBD were included. Dengue was confirmed by serology followed by determination of complete blood picture (CBC), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, D-Dimer, liver function test. All the samples were also screened for malaria, typhoid, HCV, HBV infections. Out of 306 cases 96 were confirmed as DHF. About 95.8% patients were presented with myalgia and 88 had headaches. No splenomegaly or hepatomegaly was detected. The serologic antibodies were found in all patients. Average platelet count and TLC were 47.2x103 /ul and 5.3x103/ul respectively. 83 patients had prolonged PT while 92 patients had prolonged APTT value. Total bilirubin was found raised in 7 patients, alkaline phosphatase in 91 patients and serum glutamic-pyruvic transaminase (SGPT) in 87 patients. Highly raised D-Dimer values were recorded in 96% cases while only 12% patients had higher fibrinogen levels. No co-morbity was observed in any patient. Marked hematological and haemostatic abnormalities were observed among all the patients diagnosed with DF regardless of age, sex and clinical presentation