Liena de Regla Ponce
University of Havana, Cuba
Title: Evaluation and characterization of the antiviral activity of Sargassum fluitans against some Echovirus 9, Poliovirus 1, Coxsackievirus 5 and 24
Biography
Biography: Liena de Regla Ponce
Abstract
Nature is a prominent source of broad amount of compounds derived seaweeds and plants with vary antimicrobial and antiviral activities. Seaweeds exhibit a number of medicinal properties, playing a fundamental role by curing many diseases. Their medicinal use by population makes them an interesting target to be evaluated as antivirals, taking into account the variety of chemical metabolites they own. It has been documented that Sargassum genera are an interesting target for treating many viral diseases cause by herpesevirus. However, the antiviral activity of Sargassum fluitans against these viruses is not very well documented in bibliography. The aim of this work was to evaluate the antiviral activity of extracts from Sargassum fluitans, against enteroviruses like Poliovirus 1, Coxsackievirus B5 and A24 and Echovirus 9.
The calculation of antiviral activity (EC50) was evaluated by means of cytopathic effect inhibition in Vero cells and with viral load using quantitative RT-PCR. Preliminarily, assays with hidro-ethanolic extracts showed that Sargassum species were non-cytotoxic at the evaluated concentrations and showed an inhibitory activity by diminishing the viral titer more than three log in relation to the virus control. The preliminary characterization of the extracts showed several active compounds such as sulfated polysaccharides