Ting-Chao Chou
PD Science, LLC ,USA
Title: Computerized Simulation of Anti-HIV Drug Synergy in Vitro and in Clinical Trials Using the Chou-Talalay Combination Index Method
Biography
Biography: Ting-Chao Chou
Abstract
Drug combination is most widely used in the treatment of the most dreadful diseases such as AIDS and cancer. Quantitative determination of synergism is essential for efficient discovery and development of anti-HIV cocktails. Currently, the most widely used synergy assessment of all time is the combination index (CI) method (Chou TC and Talalay P, Adv. Enz Regul 22:28-55, 1984), one article alone has been cited by 4,357 scientific papers in 850 different bio-medical journals ["Google Scholar Citations - Ting-Chao Chou" ; or Thomson Reuters Web of Science: "http://www.reseracherid.com/rid/B-4111-2009"]. This presentation will focus on theoretical basis, experimental design, general equations, simulation algorithms and computerized simulation of synergism and antagonism at different dose and effect levels. Computer software, Compusyn, will be used for automated, quantitative simulation of synergism (CI<1), additive effect (CI=1) and antagonism (CI>1) automatically. The CompuSyn instantly generated the dose-effect curves, the Median-Effect plots, Fa-CI plots, the Fa-DRI plots and their Tables, isobologram for 2-drugs, and the polygonogram for n drugs, within seconds. This software, has been offered for free download upon registration, as a donation to the bio-medical communities and pharmaceutical industries beginning 8/1/2012 upon registration, via www. combosyn.com. As of Aug. 20, 2015, there have been 11,085 downloads by bio-scientists from 87 countries or territories.
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