Zil-e-Rubab
Ziauddin University, Karachi-Pakistan
Title: Association of High Risk Human Papilloma Virus Genotypes with Oral Squamous Cell Carcinoma among Pakistani Patients
Biography
Biography: Zil-e-Rubab
Abstract
In Pakistan oropharyngeal cancer is the second leading malignancy attributed to the extensive use of smokeless tobacco products. In many studies, the high risk genotypes of HPV are proven to play a key role in oral squamous cell carcinoma (OSCC).There is a considerable diversity in the epidemiology of high risk HPV genotypes in different countries. The objective of this study was to find out the association between high risk HPV genotype in oral rinse of patients with OSCC and pre malignant oral lesions. In this case-control study, 200 samples of oral rinse were analyzed by PCR. A significant association between HPV and OSCC was found (OR=3.14, 95% CI=1.6750-5.8969, P value=0.0004).There was positive association between presence of both HPV 16/18 and OSCC but it was not significant possibly due to small sample size (OR=3.2381, 95% CI=0.8208-12.7752, P value=0.0934). As a result of these findings, HPV and predominantly genotypes 16 and 18 may be associated with the development of OSCC in Pakistan.