Rebecca D Parr
Stephen F Austin State University,USA
Title: A new antiviral therapeutic strategy for the prevention of rotavirus infections
Biography
Biography: Rebecca D Parr
Abstract
Rotaviruses (RV) are one of the leading causes of severe diarrhea in young children throughout the world. According to the WHO, rehydration, zinc supplements, nutrient-rich foods, and the availability of health professionals are key measures to treat diarrhea, but there is poor availability of interventions in developing countries. Three vaccines are available, but they only reduce the viral load, lessoning symptoms while the virus still replicates. Therefore, the search for a cost-effective therapeutic is important in reducing morbidity and mortality of RV infections in developing countries. The purpose of our studies is to investigate the effects of highly purified small molecules extracted from peanut (Arachis hypogaea) hairy root cultures. The desired effects include prevention of diarrheal symptoms and the establishment of a robust protective immunity. Recent studies show that selected natural products and synthetic small molecules inhibit specific viruses, bacteria and parasites. Stilbenoids are small molecules composed of polyphenolic compounds functioning as phytoalexins which are secondary metabolites with antimicrobial activity. They are produced by grapes, peanuts and some berries. The stilbenoid resveratrol demonstrates strong antioxidant and chemo-preventive properties. Our laboratory tested four highly purified stilbenoids to determine their effects on the RV replication in a human intestinal cell line. Our data shows a significant decrease in the amount of virus progeny with the addition of two of the four stilbenoids tested. A possible explanation of the observed effects is due to the ability of the stilbenoids to bind to cellular receptors present on the cell lines used in this study.
