Francielle Tramontini Gomes de Sousa
University of California –Berkeley, USA
Biography
Francielle Tramontini Gomes de Sousa has her expertise on dengue pathogenesis and evaluation of antiviral activity and mechanism of action of natural and semi-synthetic compounds. She has developed an in vitro co-culture model of endothelial cells and monocytes to screen compounds with therapeutic potential for management of endothelial extravasation in severe dengue. In a previous work, she had shown that serum from acute severe dengue patients differentially affects endothelial cells barrier function in vitro and found some correlations between immunomediators and vascular leakage. Her current interests include studying the pathogenic mechanism of dengue vascular leak as well as searching for therapeutic candidates against dengue virus by using in vitro (endothelial cells) and in vivo (murine) models.