Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

10th International Virology Summit

Vienna, Austria

Mu Kuan Chen

Mu Kuan Chen

Changhua Christian Hospital, Taiwan

Title: Pinosylvin decreases matrix metalloproteinase-2 expression and suppress oral cancer cell invasion and migration

Biography

Biography: Mu Kuan Chen

Abstract

Oral squamous cell carcinoma (OSCC) is the most common primary malignancy occurring in the head and neck. It is the fourth most common male cancer and the fourth leading cause of male cancer death in Taiwan. Metastatic tumors are extremely common in the late stages of cancer. Treatment for metastatic cancer aims to decelerate the growth or spread of cancer. The extracellular matrix degradation involves various proteases such as matrix metalloproteinase (MMPs), are calcium-dependent zinc-containing endopeptidases. MMP-2 is type-IV collagenases of MMPs, and correlated with lymph node metastasis and advanced tumor stage groups. Pinosylvin, a preinfectious stilbenoid toxin, is used to study its properties as a fungi toxin and therapeutic agent. Pinosylvin is used as a representative stilbene to study its biological actions and therapeutic value in processes such as cell survival, apoptosis and cell mobility. However, the pharmacological activities of pinosylvin in anti-metastasis remain unclear. In this study, we used wound closure assay and transwell assay to determine the effects of pinosylvin on oral cancer cell migration and invasion. Pinosylvin treatment significantly inhibited the migration and invasion abilities of oral cancer cells in vitro. Gelatin zymography results revealed that pinosylvin inhibited MMP-2 activity. In addition, pinosylvin suppressed carcinoma-associated epithelial–mesenchymal transition in oral cancer cells. Pinosylvin inhibits the invasion of human oral cancer cells and is a potential chemopreventive agent against oral cancer metastasis.