10th International Virology Summit
Chonbuk National University (CBNU), Republic of Korea
Title: Comparative pathogenicity of Type 1 and Type 2 Porcine Reproductive and Respiratory Syndrome virus in pregnant sows
Biography: Chang-Gi Jeong
Porcine reproductive and respiratory syndrome (PRRS) is a challenging threat to the swine industries caused by PRRS virus and characterized by reproductive failures in pregnant and respiratory distress in piglets. As an RNA virus, PRRSV mutated quickly and evolved continuously, which caused huge genetic and antigenic variation within genotypes or even in the same viruses. Furthermore, the biological properties of PRRSV responsible for viral pathogenesis and host-immune responses have not been characterized clearly. Many previous studies have been conducted by using a respiratory disease model in weaned piglets for convenience but the reproductive disease caused by PRRSV is still poorly understood. Therefore, the present study was aimed to demonstrate the pathogenicity and immune response following infections with both type 1 (D40 and CBNU0495) and type 2 (K07-2273 and K08-1054) PRRSV strains in pregnant sows. Two pregnant sows were infected with each virus at 93 days of gestation. At 21 days after infection, all sows and their fetuses were euthanized for pathological evaluation. In addition, viral loads were measured in serum samples from the sows and various tissues collected from the sows and their fetuses and fetal weights were recorded. In results, CBNU-0495 and K08-1054 showed higher virulence as compared with other viruses as they exhibited higher levels of viral loads in sera and tissues of sows and fetuses and also caused higher levels of weight losses in fetuses.