10th World Congress on Virology and Mycology
Singapore City, singapore
Mashhad University of Medical Science, Iran
Title: High prevalence of HPV in odontogenic cysts
Biography: Mohammad Amin Khajavi
Human papilloma virus is one of the DNA viruses which seems to be a causative factor in benign and malignant epithelial proliferation by synthesis of special oncoproteins so that they are considered as etiologic or cofactors in odontogenic cysts. Up to now, limited studies evaluated the presence of this virus in odontogenic cysts and tumors and also their conflicting results made it hard to conclude. Further studies are needed to make a rational hypothesis related to the role of these viruses in the development of odontogenic lesions. The aim of this study was to evaluate the presence of HPV in odontogenic cysts.
Material and method
85 cases of odontogenic cysts from archive of oral and maxillofacial pathology department of Mashhad dental school were collected. All cases were deparafinized and subsequently hydrated after that DNA was extracted from spicemens. By PCR technique the presence of HPV was evaluated.
85 odontogenic cysts evaluated in our study including 20 periapical cysts, 20 dentigerous cyst(DC), 25 Calcifying odontogenic cyst (COC) and 20 Odontogenic keratocyst (OKC). Regarding to our results prevalence of HPV in periapical cyst were 15% , in OKC 25 % , in DC 15% , in COC 24% ( Ia 18.18% , Ib 25% , Ic 16.6 % , II 50% ). Statistical analysis showed that there is a statistically significant difference regarding to prevalence of HPV only between COC Ia, Ib, Ic types.
According to high prevalence of HPV in odontogenic cysts, we concluded that these viruses may have a role in etiology and pathogenesis of these lesions.