Antiviral Research

We know that viruses are obligatory and intracellular parasites, since that replication requires the pathways and functions of the host cell. As a consequence, it is laborious to characterize specific functions of infectious viruses as god enough targets for anti-infective therapy. Nevertheless, in the past 50 years significant progress has been made towards the development of effective and specific antivirals. Particularly, HIV, Hepatitis type B & C viruses, which are of causing chronic infections and those are affecting millions of mankind world-wide, are a extensive spotlight of research in antivirals. Earlier these antivirals were directed against virus-specific enzymes but nowadays research. Initially, antivirals were mainly directed against virus-specific enzymes; currently, drugs are inhibiting the steps of infectious viral entry or release has been developed. Enlightened paths towards drug development have become progressive successful as a result of characterization structure and function of viral proteins and molecular mechanisms of virus-host interactions. Innovative strategies are exploring in essential research or preclinical studies including paths to target host factors those are important for replication of infectious virus, exploitation of the innate immune response system along with utilisation of gene silencing strategies targeting at meddlesome with the gene expression of infectious virus. Nowadays various virostatics targeting various viral replication steps are approved to treat critical infectious viral diseases. Even though, the employment of such drugs is finite by the swift development of antiviral resistance, which results a substantial complications of contemporary antiviral therapy.

  • Antiviral drug
  • VTAs (Virus-targeting antivirals)
  • HTAs (Host-targeting antivirals)
  • Antiviral mechanisms of human defensins
  • Antiviral drug resistance

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