Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 9th International Virology Congress and Expo London, UK.

Day 1 :

Keynote Forum

Giulio Filippo Tarro

Foundation de Beaumont Bonelli for Cancer Research, Italy

Keynote: Migratory phenomena, bioethics and vaccinations
OMICS International Euro Virology 2017 International Conference Keynote Speaker Giulio Filippo Tarro photo
Biography:

Giulio Filippo Tarro has graduated from Medicine School, Naples University (1962). He was a Research Associate, Division of Virology and Cancer Research, Children’s Hospital (1965-1968), Assistant Professor of Research Pediatrics, College Medicine (1968-1969), Cincinnati University, Ohio.  He was an Oncological Virology Professor, Naples University (1972-1985). Since 2007, he was the Chairman of Committee of Biotechnologies, World Academy Biomedical Technologies, UNESCO, Adjunct Professor Department Biology, Temple University, College of Science and Technology, Philadelphia, recipient of the Sbarro Health Research Organization Lifetime Achievement Award (2010). He is the President Foundation de Beaumont Bonelli for Cancer Research.

Abstract:

The evolution of the HIV following migratory phenomenon’s is reported in an interesting study carried on for 15 years. Polymerase chain reaction (PCR) is a technique in molecular biology that amplifies a specific region of deoxyribonucleic acid (DNA), and has been useful in the molecular characterization of viruses as poxviruses. In many countries, among which Italy - the vaccinations are included in the so-called sanitary obliged not coercive treatments. This means that the obligation is anticipated for all the subjects belonging to one determined range of age to undergo to some vaccinations, but that these are not subministrated by force in case of refusal. The legitimacy of the imposition of the obligatory vaccination against smallpox, with all the risks connected, observing how such "risks were too much reduced to be seriously taken in consideration for the benefits produced on the collectivity". To ratify this obligation brings to the reimbursement of the damages produced by the vaccination. Nevertheless, mass vaccination against smallpox continues to be a leading initiative in Western countries to guard against bioterrorist attack. 

OMICS International Euro Virology 2017 International Conference Keynote Speaker Sita Awasthi photo
Biography:

Sita Awasthi has received her Ph.D in Biochemistry from Devi Ahilya University at Indore, India and her postdoctoral training from University of Pennsylvania at Philadelphia. Currently she is a Research Associate Professor at University of Pennsylvania, Pearlman School of Medicine, Infectious Disease Division. Her research interests are preventative and therapeutic HSV-2 vaccine development against genital herpes disease, and HSV-2 HIV-2 co-infections.  She has published numerous research articles and serving as an editorial board member of Journals of antivirals and anti retrovirals, Journal of Immunoassay and Immunochemistry.
 

Abstract:

There are approximately half a billion people infected with herpes simplex virus type 2 (HSV-2) worldwide. Genital herpes infection increases the risk of HIV acquisition and transmission by 3- to 4-fold. A successful genital herpes vaccine will help curb two overlapping epidemics. We have designed a protein subunit-based therapeutic vaccine that will treat individuals already infected with HSV-2. The goals of a therapeutic vaccine are to reduce recurrent genital lesions (disease) and subclinical infection, as measured by genital shedding of HSV-2 DNA and infectious virus. Subclinical infection is an important target as it accounts for much of the sexual transmission of genital herpes. We evaluated a trivalent subunit antigen vaccine consisting of HSV-2 glycoproteins C, D and E (gC2, gD2, gE2) with the intent of blocking virus entry mediated by gD2; blocking virus attachment to cells, and inhibiting innate immunity mediated by complement by gC2; and blocking cell-to-cell spread and immune evasion from antibody mediated by gE2. We administered gC2/gD2/gE2 with CpG, a TLR9 agonist that enhances CD8 T cell responses, and alum, to stimulate antibody production. The vaccine was administered 3 times at two-week intervals to guinea pigs that were previously infected intravaginally with HSV-2. The vaccine significantly boosted gC2, gD2 and gE2 antibody levels as well as enhanced neutralizing antibody titers. The mock-immunized animals had recurrences on 48 of 624 days (7.7%) compared with 29 on 738 days (3.9%) in the trivalent group, which represents 49% fewer recurrent lesion days. The impact of the vaccine was apparent from the time of the first immunization. In addition, a significant reduction in vaginal shedding of HSV-2 DNA 52% (P=0.039) was noted compared to mock vaccinated animals, which did not become apparent until the third immunization. We evaluated the recovery of infectious virus from vaginal swabs following the third immunization, as we consider infectious virus a relevant marker for risk of transmission. Infectious virus was isolated on 5/26 (19.2%) days when mock-immunized animals were shedding HSV-2 DNA compared with 1/11 (9.1%) days when the trivalent-immunized animals were shedding HSV-2 DNA. Although this difference was not statistically significant, the results raise the interesting possibility that immunized animals are less likely to infect sexual partners even when shedding HSV-2 DNA. We conclude that therapeutic immunization reduces the number of days animals have genital lesions and genital shedding of HSV-2 DNA, and that on days with vaginal shedding of HSV-2 DNA, immunized animals are less likely to be shedding infectious virus compared to mock-immunized animals.