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10th World Congress on Virology and Mycology

Singapore City, singapore

J. Joonu

J. Joonu

Bishop Heber College, India

Title: Risk of Human papilloma virus in causing cervical cancer and the recent advancement in vaccination as a preventive measure

Biography

Biography: J. Joonu

Abstract

Viruses account for about 20% of total human cancer cases. Although many viruses can cause various tumors in animals, only seven of them are associated with human cancers and are currently considered oncogenic viruses. These viruses include hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV), Epstein Barr virus (EBV), human herpes virus 8 (HHV8), Merkel cell polyomavirus (MCPyV), and HTLV-1. High-risk HPV strains are the major causes of cervical cancer and other ano-genital neoplasms as well as a significant proportion of head and neck tumors.

The molecular mechanisms of viral oncogenesis are complex and may involve the induction of chronic inflammation, disruption of host genetic and epigenetic integrity and homeostasis..

The push to vaccinate girls in the age of 9:

HPV is recognized by mainstream medical authorities as the most commonly sexually transmitted infection in the US with an estimated 20 million persons infected and over 6 million new infections annually.  Merck, the maker of the HPV vaccine Gardasil, presented information to the Food and Drug Administration (FDA) prior to approval that their vaccine increased the risk of pre-cancerous changes by 44.6% in women exposed to HPV types 16 or 18 pre-vaccination. HPV vaccines have been shown to prevent cervical dysplasia . The protection against HPV 16 and 18 has lasted at least 8 years after vaccination for Gardasil and more than 9 years for Cervarix.