10th World Congress on Virology and Mycology
Singapore City, singapore
King George’s Medical University, India
Title: Neurologic complications of dengue virus infection
Biography: Amita Jain
Statement of the Problem: Dengue virus infection is an extremely common mosquito borne infection in the world. Neurologic complications are increasingly being reported in dengue cases affecting both the central and peripheral nervous system. This session is aimed to discuss the incidence and clinical spectrum of neurologic complications of dengue, methods of their diagnosis, management and outcome in patients with dengue virus infection.
Methodology & Theoretical Orientation: An extensive review of the published literature was carried out using Pubmed, Scopus and Google Scholar databases. The keywords used were “Dengue and neurological”, “Dengue and neuropathy”, ”Dengue and Plexopathy”, “Dengue and Acute Encephalitis Syndrome”, “Dengue and Encephalopathy”.
Findings: The neurologic manifestations may be seen in 0.5- 7.4% of dengue cases. These include encephalopathy, encephalitis, aseptic meningitis, stroke (intracranial hemorrhages or thrombosis), myelitis, Guillain Barre syndrome, plexus involvement (brachial plexopathy, neuralgic amyotrophy, lumbosacral plexoopathy), nerve involvement (mononeuropathies, polyneuropathies) and muscle involvement (myalgias, myositis, rhabdomyolysis, hypokalemic paralysis). Diagnosis of dengue virus infection may be made by a combination of dengue NS1Ag/Real Time PCR and anti-IgM antibody in CSF. In serum samples, dengue infection may be confirmed by PCR/culture positivity, IgM detection or by four fold rise in titers of specific IgG antibodies in paired serum samples.
Conclusion & Significance: In endemic regions dengue should be considered as a differential diagnosis of neurological disorders. Early recognition of these complications is required for proper management of cases and for preventing further disabilities.