Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 13th World Congress on Virology and Infectious Diseases Tokyo, Japan.

Day 1 :

Keynote Forum

Rahul Hajare

Indian Council of Medical Research

Keynote: Why Tall individuals More Prone to Cancer in India
Conference Series Virology Asia 2020 International Conference Keynote Speaker Rahul Hajare photo
Biography:

Dr. Rahul Hajare has been a hard worker all his academic life. After his Ph.D in Pharmacy from VMRF Salem which he completed with flying colours, he is fortunate to work NARI primer HIV research Institute to complete Post Docunder the of World Renowned Scientist Respected Dr. R.S.Paranjape., Retired Director & Scientist ‘G’ National AIDS Research Institute Pune. Dr. Rahul Hajare has Associate Professor of Pharmaceutical Medical Chemistry to Pune University (until 2020), he has serviced three times AssociateProfessor in Pharmaceutical Science and Analytical Science. Graduated from Amravati University in 2003, after an assignment he worked as an M.Pharm Scholar in the Institute of Pharmaceutical Education and Research passed with distinction, he has Post Graduate Teacher for Master of Pharmacy, he has more than 30 scientific and methodological works, 3 patents of scientific research.

 

Abstract:

Tall individuals are at increased risk of almost all cancers, "But skin cancers such as melanoma show an unexpectedly strong relationship to height. This may be because the hormone IGF-1 is at higher levels in taller adults." IGF-1 is a growth factor that is particularly important in early development, but IGF-1 has also been linked to a higher rate of cell division in tall adults [3]. "If cells divide more often, then that adds to cancer risk."If skin cells are dividing more rapidly in tall people due to high levels of IGF-1, then this could account for the increased risk for melanoma." Of the 18 cancers scored in both sexes, Nunney found only four showed no significant increase with height in either sex: pancreas, esophagus, stomach, and mouth. "It is possible that these cancers are more strongly associated with environmental factors."It has, too, that in these tissues cell numbers do not scale with body size but this seems unlikely." Nunney explained that two factors cause increased cancer risk: one is having more cells; the other is having more cell divisions. If double the cells, double the cancer risk. ”If double the number of cell divisions, more than double the cancer risk. Living a long time is the worst thing to do if want to avoid cancer.

 

Keynote Forum

Dr. RohitJain

PennState Hershey Medical Center, Hershey

Keynote: Mesenteric Masking of Mycobacterium Tuberculosis
Conference Series Virology Asia 2020 International Conference Keynote Speaker  Dr. RohitJain photo
Biography:

Rohit Jain,MD is current academic hospitalist at Milton S. Hershey PennState Medical Center in central PA since 2016 and completed residency from St-Agnes Hospital Baltimore Maryland USA. He also completed fellowship in geriatrics from University of Maryland. He has published more than 14 papers in reputed journals and also has been serving as an reviewer to multiple society related to field of medicine. He is also interested in public health so at present he is pursuing master in public health from John Hopkins University Baltimore MD.

 

Abstract:

26 year-old Indonesian woman presented with a two week history of low back pain and abdominal pain.She denied any traumatic injury, nausea, vomiting, fevers, chills, or weight loss at the time. She had last traveled to Indonesia six months prior to presentation. Abdominal CT revealed diffuse necrotic mesenteric lymphadenopathy. Chest CT revealed nodules with no other abnormalities.Patient underwent bronchoscopy for AFB and after several days the AFB cultures from bronchoscopy and the lymph node biopsy returned positive for Mycobacterium Tuberculosis.

Patient was started on   rifampin,isoniazid,pyrazinamide,and ethambutol.Classically TB  present with hemoptysis, fevers,night sweats, and weight loss.This case shows atypical presentation of TB with necrotic mesenteric lymphadenopathy causing abdominal pain and referred low back pain.The differential diagnosis for mesenteric lymphadenopathy includes lymphoma, sarcoidosis, tuberculosis, Epstein-Barr virus, and cytomegalovirus so one should always take a thorough travel history if even a slight suspicion exists for TB on a differential.

 

Conference Series Virology Asia 2020 International Conference Keynote Speaker Dr Ren Jye Lin photo
Biography:

Abstract:

Zinc finger protein 36, CCCH type-like 1 (ZFP36L1), a member of the ZFP36 family (also named as TIS11family) of CCCH-type zinc finger proteins, are generally thought of as RNA-binding proteins and identified to play an important role in the regulation of the cellular gene expression at post-transcriptional or translation levels. However, the antiviral potential of ZFP36L1 has not been identified so far. Here, we demonstrate for the first time that ZFP36L1 functions as a host innate defender against flaviviruses including Japanese encephalitis virus (JEV) and dengue virus (DENV). Ectopic overexpression of ZFP36L1 restricted JEV and DENV infection, and knockdown of ZFP36L1 enhanced viral replication. ZFP36L1 destabilized JEV genome by targeting and degrading viral RNA through recruiting both 5¢-3¢ XRN1-mediated and 3¢-5¢ RNA exosome-mediated RNA decay pathways. Mutation in both of the zinc-finger motifs of ZFP36L1 showed the disruption of antiviral activity. 

Conference Series Virology Asia 2020 International Conference Keynote Speaker Dr Yuriko Hagiwara photo
Biography:

Dr Kiyosu Taniguchi has completed his MD in 1984 from Schoolf of Medicine, National Mie Univeristy. He is the Director, Department of Clinical Research, National Mie Hospital, Japan. He was the former Head of 1st Division, Infectious Disease Surveillance Center, National Institute of Infectious Diseases. He also served at World Health Organization headquarters, and worked for international infectious disease surveillance and control program. Dr. Taniguchi is a board of councilors of Japanese Association for Infectious Disease, editorial board for Japanese Society for Vaccinology. In addition, he is a member of the pandemic preparedness committee of MHLW.

Abstract:

Background: Elderly populations are particularly vulnerable to influenza and often require extensive clinical support. In Japan, nationwide passive sentinel surveillance monitors seasonal influenza but does not capture the full disease burden. We synthesized existing evidence on epidemiology, vaccine effectiveness (VE) and costs of seasonal influenza in the elderly population aged over 50yrs. Methods: PubMed, EMBASE, and ICHUSHI search for articles describing seasonal influenza in Japan, published between 1997 - 2018, in English or Japanese. Grey literature was also assessed. A random-effects meta-analysis characterized VE of standard dose vaccines among studies reporting this information. Results: Of 1,147 identified articles, 143 met inclusion criteria. Reported incidence rates varied considerably depending on study design, season, study setting and, most importantly, case definition. In nursing homes, influenza attack rates were as high as 55.2% and aged persons suffered significant influenza disease burden, hospitalizations, and mortality. Renal diseases were the most commonly-reported comorbidity. Most hospitalizations were in people aged >60. In metaanalysis, overall VE was 19.1% (95% CI: 2.3% - 33.0%) with high heterogeneity (I 2 : 89.1%). There was a trend of lower VE in older people (40.1% in the <65 group; 12.9% in those ≥65; p = 0.21). Additional healthcare costs were partially mitigated by vaccine administration. Conclusions: Despite differences between studies that make comaparisons challenging, the influena burden in elderly Japanese is significant. Influenza VE and related socioeconomic outcomes data were limited and lack generalizability. Further research on influenza management for this population is warranted with an emphasis on characterizing the benefits of prevention.

Conference Series Virology Asia 2020 International Conference Keynote Speaker Md. Naushad Khan photo
Biography:

I am Md. Naushad khan doctoral fellow in Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard University, India. I did complete the Master of Philosophy from the Jamia Millia Islamia University, India. Currently, I am publishing the four papers and participate as a speaker in the National and International Conferences. I have experience in research fields since 2011

Abstract:

Chikungunya fever is an emerging arboviral disease caused by the chikungunya virus (CHIKV). While many CHIKV infected patients recover after primary illness, others suffer from persistent debilitating arthralgia that can last for months to years. There is an urgent need to understand the epidemiology, pathogenesis and determine the disease burden due to chikungunya. We, therefore, used molecular diagnostic tests for the detection of CHIKV infections at Jamia Hamdard Institute of Medical Sciences (JHIMS) hospital in New Delhi and assessed viral diversity of infecting strains and clinical characteristics associated with chikungunya disease. We enrolled 325 acute febrile patients suspected to have CHIKV infection. All samples were screened by RT-PCR (One-step RT-PCR kit, Qiagen), IgM ELISA (SD Chikungunya IgM ELISA kit). Whole CHIKV genome sequences were carried out for chikungunya RT-PCR positive samples and assessed by phylogenetic analysis. Whole-genome sequence analysis of CHIKV structural and nonstructural gene showed the maximum number of mutations in the structural gene compare to nonstructural gene this is comparable to the prototype ECSA strains, of CHIKV and physiochemical properties of proteins, was also assessed by in silico approach. The study emphasizes the need for continuous surveillance for disease burden using multiple diagnostic tests, characterization, changes in vector-pathogen compatibility and host-pathogen interactivity for the development of suitable vaccine candidates and antivirals.

 

 

 

 

Conference Series Virology Asia 2020 International Conference Keynote Speaker Dr Hajar Chihab photo
Biography:

Dr Hajar  completed my PhD since May 21th, 20219 from Chouaib Doukkali University in Morocco and Institut Pasteur du Maroc. I‟m actually a postdoctoral fellow candidate. I have seven publications in reputed journals.

Abstract:

Despite the effectiveness of antiviral therapy using nucleos(t)ide analogues (NAs), drug resistance is still a major obstacle for the long term efficacy of antiviral therapy in chronic hepatitis B. Mutations can occur spontaneously and naturally in HBV reverse transcriptase (RT) region as minor viral population in naive patients and can emerge as major viral population, conferring drug resistance and treatment failure. The aim of this study was to analyze mutations within the HBV polymerase gene in treatment naive Moroccan patients with CHB. A total of 123 treatment-naïve HBV-infected individuals were included in this study. The HBV polymerase gene was analyzed by PCR and direct sequencing. HBV RT region mutations and amino acid changes were analyzed in BioEdit, by comparing the obtained sequences with a set of HBV reference sequences, HBV genotypes were determined using Geno2pheno HBV Database. Sixty- samples were successfully amplified by PCR. Our results showed low frequencies of classical primary drug resistance mutations (3%), (13%) of non-classical pre-treatment mutations, and a high frequency of nonclassical putative NA resistance mutations (65%). Among these, 56% were lamivudine resistance mutations, and 44% adefovir resistance mutations. A single primary resistance mutation to adefovir, „A194T‟ was detected in 2/60 CHB patients, two pretreatment mutations in 8/60 patients, and 11 putative resistance mutations in 39/60 patients. These results confirm that HBV mutations which confer resistance against currently available anti-HBV NA, may already exist in patients who have never received NA treatment.

Conference Series Virology Asia 2020 International Conference Keynote Speaker Mr Ehsan Kamani photo
Biography:

I am Ehsan Kamani was born in 1994 in Iran. I am a graduate of the field of optics and laser engineering. I started studyingand Research the use of lasers in medicine since 2014. I am mighty in the field of laser I have an intense internal drive . I am eager to learn and study further.medicine research and treatment and passion, and the willingness to take a chance, to fail if necessary, and to start the process all over again. I have a passion for research to be able to make life better for people affected by diseases and it is far more important than anything to me. Working in a place nearby cancer department of Shohada University and watching patients affected by cancer complications made me think how I can help these people.when I face new issues,I look at it and think, ‘that seems interesting, that could be an area I could make a contribution in,maybe I can make a difference’ then I invest myself in it,” “I take my time and life to do it, I encounter challenges and make my way through it.I choose University due to the chance that has given to me with its superb reseach expertise.Reasearch is my passion.

Abstract:

In the name of Creator of Light Laser is a technology used in various medical fields. After the revolution, Penny Celine has been in the medicine of this laser, which has revolutionized medicine I have studied and studied laser applications in medical sciences, and I have been able to get the right information in this area. Application of laser in drug delivery of cancer tissue: Using a laser and a method for making drugs with nanoparticles, we can use the laser wavelength and appropriate selection of drugs and nanoparticles to target tissues that are used in drug delivery. People with cancer have an important role in minimizing the side effects of chemotherapy Application of Lasers to Improve Endocrine Activity: By using appropriate wavelength lasers and energy, we can influence the process of recovery of the activity of the glands, which is used to improve the thyroid gland, pancreas and saliva.  Application of laser in lowering blood pressure: Using low-level lasers can be treated intraarticular and topically in the process of reducing blood pressure.  Laser application in blood cell proliferation: We can play an important role in laboratory culture using laser light and proper wavelength in the process of white blood cell proliferation, red blood cells, and platelets. This process is important in patients with over-the-counter It will play an important role.Laser application in the treatment of depression: This method will be performed using appropriate light and energyApplication of Lasers in Acupuncture: Using a low-power laser and appropriate acupuncture points, we can treat the following illnesses. 1 - Obesity 2 - Depression 3 - Impotence - Muscle pain Paralysis Application of laser in preventing ulcers in chemotherapy patients Application of laser in wound healing of diabetic people Laser application in the treatment of fungus nails with specific color and appropriate laser length Making laser machine for diagnosis as soon as possible

Conference Series Virology Asia 2020 International Conference Keynote Speaker Dr Sineewanlaya Wichit photo
Biography:

Dr. Sineewanlaya Wichit has completed her PhD from University of Montpellier, France. She is the permanant staff of Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Thailand. She has published more than 16 papers in reputed journals. She works mainly on Virology especially arbovirus such as Chikungunya, Zika and Dengue virus. After Master degree in Tropical Medicine, Dr. Wichit worked as a research assistant at Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand for 8 years. Then, she took three years to do her PhD in Virology as well.    

Abstract:

Chikungunya virus (CHIKV) and Zika virus (ZIKV) are emerging arboviruses that pose a worldwide threat to human health. Currently, neither vaccine nor antiviral treatment to control their infections is available. As the skin is a major viral entry site for arboviruses in the human host, we determined the global proteomic profile of CHIKV and ZIKV infections in human skin fibroblasts using Stable Isotope Labelling by Amino acids in Cell culture (SILAC)-based mass-spectrometry analysis. We show that the expression of the interferon-stimulated proteins MX1, IFIT1, IFIT3 and ISG15, as well as expression of defense response proteins DDX58, STAT1, OAS3, EIF2AK2 and SAMHD1 was significantly up-regulated in these cells upon infection with either virus. Exogenous expression of IFITs proteins markedly inhibited CHIKV and ZIKV replication which, accordingly, was restored following the abrogation of IFIT1 or IFIT3. Overexpression of SAMHD1 in cutaneous cells, or pretreatment of cells with the virus-like particles containing SAMHD1 restriction factor Vpx, resulted in a strong increase or inhibition, respectively, of both CHIKV and ZIKV replication. Moreover, silencing of SAMHD1 by specific SAMHD1-siRNA resulted in a marked decrease of viral RNA levels. Together, these results suggest that IFITs are involved in the restriction of replication of CHIKV and ZIKV and provide, as yet unreported, evidence for a proviral role of SAMHD1 in arbovirus infection of human skin cells.

 

Conference Series Virology Asia 2020 International Conference Keynote Speaker Mr Hayatudeen Muhammad Rumah photo
Biography:

Abstract:

Herpes Simplex Virus type 2 (HSV-2) is a significant public health problem being one of the most prevalent sexually transmitted infections worldwide and the leading cause of genital ulcerative disease that is common both in industrialized and developing countries. Therefore, a study on the Incidences and possible risk factors associated with subclinical genital herpes among different populations in Katsina State, north-western Nigeria was carried out. A total of 460 (86 HIV, 136 feverish patients, 125 pregnant women and 113 normal Individuals) blood samples were collected from six hospitals located across the three senatorial zones of the State. The serum were separated from the blood and used for the analysis. The participant’s socio-demographic information and clinical presentations were also noted with the aid of a questionnaire. HSV-2 IgM were detected by enzyme-linked immunosorbent assay. The HSV-2 IgM were detected in 41.5% of all the serum tested. The seroincidence of IgM among patients presenting with fever was 29.4%, and 40.0% for IgM in the pregnant women. The seroincidence of IgM among HIV positive patients was 24.4% while it was 46.0% in the apparently healthy individuals. There was a significant association between HIV positivity, feverish condition and IgM seroincidence. Higher seroincidence was recorded at General Hospital Dutsinma 89.6%. Generally, older participants were more vulnerable to HSV-2 infection than younger ones and there was statistically significant association between IgM seroincidence and age of the participants. There was no statistical significant association between sex of the participants and HSV-2 infection. None of the sociodemographic factors was significantly associated with HSV-2 infection except marital status. There was no significant association between socio-economic status, sexual activity, use of protection, number of sexual partners, clinical manifestation, level of education, and occupation of the participants with HSV-2 infection. The present study indicates that seroincidence of HSV-2 appears to be relatively high and older participants were more vulnerable to HSV-2 infection in Katsina State. There is need for educating populace on HSV-2 infection and its mode of transmission to reduce the level of its spread between individuals in the population.