Coronavirus

Coronaviruses were first described in the 1960s from the nasal cavities of patients with the common cold. This virus belongs to the subfamily Coronavirinae in the family Coronaviridae. Genome replication and transcription is mediated by a multisubunit protein complex comprised of more than a dozen virus-encoded proteins, this complex thought to bind specific to the cis-acting RNA elements. Identification and characterization of DI RNAs in various coronaviruses have been instrumental in mapping the minimal RNA sequences and structures required for replication and packaging. Infection of host cell initiated by virus binding to receptors on the cells surface and subsequent fusion of the lipid bilayer of the viral envelope with the host cell plasma membrane  (mouse hepatitis virus)or endosomal membrane(human coronavirus).it binding and entryare importants determinants oof viral host range and tissue tropism . Coronaviruses can cause pneumonia, either direct viral pneumonia or a secondary bacterial pneumonia, and bronchitis, either direct viral bronchitis or a secondary bacterial bronchitis.

    Related Conference of Coronavirus

    27,28-July-2017

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    12th World Congress on Virology

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